My research goals have been largely motivated by clinical concerns. After training as a physician, I focussed on clinical medicine for a period, before moving into bench research especially feeling that advances in basic science are needed to support care with respect to brain disorders. In this context, my long-standing interests have been in stem cell biology and neurodegenerative disorders, especially Parkinson’s disease (PD). I have significant expertise with a variety of stem cells and with cellular/animal models of neurodegeneration, which has been applied over the past several years towards studying fundamental aspects of stem cell function, as well as stem cell therapeutic ability, in the context of PD. Current endeavors in my laboratory continue in this vein, and center on investigating stem cell potential within the framework of aging and PD utilizing rodent and human model systems.