Publications

Corenblum, M. J., Madhavan, L. Small-scale Propagation of Human iPSCs in Serum-free Conditions for Routine Immunocytochemical Characterization. J. Vis. Exp. (120), e55260, doi:10.3791/55260 (2017).

Umashankar A, Corenblum MJ, Ray S, Valdez M, Yoshimaru E, Trouard T, and Madhavan L.  Effects of the iron oxide nanoparticle Molday Ion Rhodamine B on the viability and regenerative function of neural stem cells: Relevance to clinical translation. International Journal of Nanomedicine 2016:11 1731–1748. PMID: 27175074

Corenblum MJ, Ray S, Remley QW, Long M, Harder B, Zhang DD, Barnes CA, and Madhavan L. Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period.  Aging Cell. 2016 Apr 20. doi: 10.1111/acel.12482. PMID: 27095375

Madhavan L, Daley BF, Davidson BL, Boudreau RL, Cole-Strauss A, Lipton JW, Steece-Collier K, and Collier TJ; Sonic hedgehog controls the phenotypic fate and and therapeutic potential of grafted neural stem cells in a model of nigrostriatal degeneration.  PLOSOne. 2015 Sep 4;10(9):e0137136. PMID: 26340267

Corenblum MJ,  Flores AJ, Badowski M, Harris DT, and Madhavan L.  Systemic human CD34+ stem cells populate the brain and activate host-based mechanisms to counteract nigrostriatal neurodegeneration. Regen Med. 2015 Aug;10(5):563-77. PMID: 26237701

Madhavan L.  Redox-based regulation of neural stem cell function and Nrf2. Biochemical Society Transactions, Biochem. Soc. Trans. (2015) 43, 627–631

Madhavan L. Chapter on Neural Stem Cells for Intrinsic Brain Repair in Aging and Neural Degeneration. Book Title: “Neural Stem Cells in Health and Disease”, World Scientific Publishing Company, Singapore. http://www.worldscientific.com/worldscibooks/10.1142/9309

Paumier KL, Sortwell CE, Madhavan L, Terpstra B, Steece-Collier K, Daley BF, and Collier TJ; Tricyclic antidepressant treatment evokes regional changes in neurotrophic factors over time within the intact and degenerating nigrostriatal system. Experimental Neurology 2015 Apr;266:11-21. PMID: 25681575

Paumier KL, Sortwell CE, Madhavan L, Terpstra B, Daley BF, and Collier TJ; Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism. Neuropsychopharmacology. 2015 Mar;40(4):874-83. PMID: 25267343

Paumier K, Siderowf A, Auinger P, Oakes D, Madhavan L, Espay Alberto RF, Collier T; Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease: a retrospective cohort study. Mov Disord. 2012 Jun;27(7):880-7. PMID: 22555881

Madhavan L, Daley B, Sortwell C, Collier TJ; Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the Parkinsonian rat. European Journal of Neuroscience; 2012; 2012 Mar;35(6):883-95. PMID: 22417168

Gombash SE, Lipton JW, Collier TJ, Madhavan L, Steece-Collier K, Cole-Strauss A, Terpstra BT, Spieles-Engemann AL, Daley BF, Wohlgenant SL, Thompson VB, Manfredsson FP, Mandel RJ, Sortwell CE; Striatal overexpression of pleiotrophin provides functional and morphological neuroprotection in the 6-hydroxydopamine model of Parkinson's Disease; Molecular Therapy; 2012 Mar;20(3):544-54. PMID: 22008908

Kordower J, Hemraj D, Kordower A, Terpstra B, Madhavan L, Paumier K, Sortwell C, Steece-Collier K, Collier T. Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat; Neurobiol Dis; 2011 Sep; 43(3):552-7. PMID: 21600984

Spieles-Engemann AL, Behbehani MM, Collier TJ, Wohlgenant SL, Madhavan L, Paumier K, Steece-Collier K, Gombash S, Mandybur GT, Lipton X, Sortwell CE; Deep brain stimulation of the rat subthalamic nucleus is neuroprotective following large scale nigral dopamine neuronal degeneration; Neurobiol Dis; 2010 Jul; 39(1):105-15. PMID: 20307668

Madhavan L, Collier TJ; A synergistic approach for neural repair: cell transplantation and induction of endogenous precursor cell activity; Neuropharmacology; 2010 May; 58 (6):835-44. PMID:19853620

Madhavan L, Paumier KL, Daley BF, Collier TJ; Transplantation of subventricular zone neural precursors induces an endogenous precursor cell response in a rat model of Parkinson's disease; J Comp Neurol; 2009 July 1; 515 (1): 102-15. PMID: 19399899

Madhavan L, Ourednik V, Ourednik J; Neural stem/progenitor cells initiate the formation of cellular networks that provide neuroprotection by growth factor modulated antioxidant expression; Stem Cells; 2008; 26: 254-65. PMID: 17962704

Madhavan L, Ourednik V, Ourednik J; Increased "vigilance" of antioxidant mechanisms in neural stem cells potentiates their capability to resist oxidative stress; Stem Cells; 2006; 24(9):2110-9. PMID: 16728559

Madhavan L, Ourednik V, Ourednik J; Grafted neural stem cells shield the host environment from oxidative stress; Annals New York Academy of Sciences; 2005; 1049: 185-8. PMID: 15965117

Madhavan L, William JF, Vellareddy A, Kanthasamy AG; 5-Hydroxytryptamine 1A receptor activation protects against N-Methyl-D-aspartate-induced apoptotic cell death in striatal and mesencephalic cultures; The Journal of Pharmacology and Experimental Therapeutics (JPET); 2003; 304(3): 913-923. PMID: 12604665